Diagenode

Platelet function is modified by common sequence variation in megakaryocyte super enhancers


Petersen R. et al.

Linking non-coding genetic variants associated with the risk of diseases or disease-relevant traits to target genes is a crucial step to realize GWAS potential in the introduction of precision medicine. Here we set out to determine the mechanisms underpinning variant association with platelet quantitative traits using cell type-matched epigenomic data and promoter long-range interactions. We identify potential regulatory functions for 423 of 565 (75%) non-coding variants associated with platelet traits and we demonstrate, through ex vivo and proof of principle genome editing validation, that variants in super enhancers play an important role in controlling archetypical platelet functions.

Tags
IP-Star
Antibody
Microplex Library Preparation kit

Share this article

Published
July, 2017

Source

Products used in this publication

  • cut and tag antibody icon
    C15410196
    H3K27ac Antibody - ChIP-seq Grade
  • cut and tag antibody icon
    C15410195
    H3K27me3 Antibody - ChIP-seq Grade
  • ChIP-seq Grade
    C15410192
    H3K36me3 Antibody - ChIP-seq Grade
  • cut and tag antibody icon
    C15410194
    H3K4me1 Antibody - ChIP-seq Grade
  • cut and tag antibody icon
    C15410003-50
    H3K4me3 Antibody - ChIP-seq Grade
  • cut and tag antibody icon
    C15410210-50
    CTCF Antibody - ChIP-seq Grade
  • ChIP kit icon
    C01010058
    Auto iDeal ChIP-seq Kit for Transcription Factors
  • ChIP kit icon
    C01010172
    Auto iDeal ChIP-seq Kit for Transcription Factors
  • ChIP kit icon
    C05010012
    MicroPlex Library Preparation Kit v2 (12 indexes)

活动

  • Long-Read Sequencing Meeting 2024
    Uppsala, Sweden
    Oct 21-Oct 23, 2024
  • NextGen Omics 2024
    London, UK
    Oct 23-Oct 25, 2024
  • FEBS 2024
    Budapest, Hungary
    Oct 28-Oct 31, 2024
  • 5th Danube Conference on Epigenetics
    Budapest, Hungary
    Oct 28-Oct 31, 2024
 查看所有活动

 


       Site map   |   Contact us   |   Conditions of sales   |   Conditions of purchase   |   Privacy policy