Chromatin shearing with the Bioruptor® Pico, 0.2 ml Bioruptor® Microtubes and the corresponding holder

The first critical step of a successful ChIP experiment is the preparation of sheared chromatin with a suitable fragment range which best represents the biological scenario being investigated. The Bioruptor^® Pico ensures that the chromatin is efficiently sheared to an appropriate and consistent fragment size. Bioruptor® shearing occurs in a temperature-controlled environment providing a high quality chromatin with preserved epitopes suitable for ChIP-qPCR and ChIP-seq experiments.