Smc5/6 silences episomal transcription by a three-step function. Published: September, 2022 Abstract:
In addition to its role in chromosome maintenance, the six-membered Smc5/6 complex functions as a restriction factor that binds to and transcriptionally silences viral and other episomal DNA. However, the underlying mechanism is unknown. Here, we ... Read more »
Regulatory interplay between Vav1, Syk and β-catenin occurs in lungcancer cells. Published: October, 2021 Abstract:
Vav1 exhibits two signal transducing properties as an adaptor protein and a regulator of cytoskeleton organization through its Guanine nucleotide Exchange Factor module. Although the expression of Vav1 is restricted to the hematopoietic lineage, i... Read more »
AP-1 controls the p11-dependent antidepressant response. Published: May, 2020 Abstract:
Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed drugs for mood disorders. While the mechanism of SSRI action is still unknown, SSRIs are thought to exert therapeutic effects by elevating extracellular serotonin level... Read more »
