Bioruptor® in Action Video
Company | Diagenode story
Diagenode is a leading global provider of complete solutions for epigenetics research, biological sample preparation, and diagnostics assays based in Liège, Belgium and Denville, NJ, USA. The company has developed both shearing solutions for a number of applications as well as a comprehensive approach to gain new insights into epigenetic studies. The company offers innovative Bioruptor® shearing and IP-Star® automation instruments, reagent kits, and high quality antibodies to streamline DNA methylation, ChIP, and ChIP-seq workflows. The company's latest innovations include a unique, full automation system, the industry's most validated antibodies including Premium antibodies® and Blueprint antibodies™, and the Megaruptor shearing system for long fragment generation in sequencing.
From Diagenode's founding in 2003 in Liège as a local biotechnology startup, the company has expanded rapidly. Diagenode has opened its US branch in 2006 and developed a global distribution and partnering network including relationships in Japan and other Asia-Pacific countries. Diagenode has been profitable since its inception. The company planned to extensively develop its range of innovative products in both epigenetics and infectious diseases markets.
Diagenode specializes in serving two fast growing markets:
1. Epigenetics research
Epigenetics is playing a revolutionary role in life sciences research. Rapid progress in this field is driving the need for new kinds of research tools and new standards for understanding the epigenetic control mechanisms involved in various biological phenomena such as disease development and drug mechanisms of action. Genome-wide tools such as Next Generation Sequencing that can assess global epigenetic changes at the histone or the DNA level dramatically advance understanding of the epigenetic mechanisms. Epigenetics research will identify new biomarkers for earlier-stage disease diagnosis and enable development of effective new therapeutics.
Epigenetic assays are complex and necessitate high-quality reagents, robust protocols, and comprehensive data analysis. Diagenode continually innovates solutions and provides the highest quality epigenetics tools available.
Our goal is to develop cutting-edge products that advance research in the rapidly evolving field of epigenetics. The company actively develops and markets a comprehensive portfolio of proprietary products that offers complete solutions for epigenetics-related research. Diagenode's Bioruptor® Sonicator is a best-in-class instrument series which provides unrivaled performance, durability, and value for shearing a wide spectrum of biological samples. Diagenode also specializes in offering a complete range of chromatin immunoprecipitation (ChIP) and DNA methylation products. The SX-8G IP-Star® Compact Automated Sytem represents the first complete system to automate ChIP and DNA methylation assays.
Products for Epigenetics
Shearing devices for DNA and chromatin preparation with a flexible range between 150 bp-75kb
- Bioruptor® Sonicators – the most cited devices for chromatin and DNA shearing between 150 bp- 2kb
- Megaruptor Shearing system -- Shear anywhere from 2kb – 75kb , perfect for mate pair library prep
Automated systems for ChIP and Library preparation for unmatched reproducibility with the IP-Star® Compact Automated System; includes protocols for high throughput and robust ChIP, MeDIP, MBD assays and NGS library preparation
Full range of ChIP and ChIP-seq kits
- True MicroChIP kit, efficient ChIP recovery and enrichment from only 10,000 cells
- iDeal ChIP-seq kit, the only kit on the market validated for GAIIx (Illumina®) and PGM™ (Ion Torrent™)
- HighCell# ChIP kit, recover more DNA and limit bias of downstream applications
- IPure kit is the only DNA purification kit using magnetic beads that is specifically optimized for DNA purification from ChIP and MeDIP
Epigenetics-focused antibodies for a wide range of targets including thoroughly validated ChIP/ChIP-seq-grade antibodies
Full DNA methylation solution including MeDIP, MBD, and bisulfite solutions
Next Generation Sequencing library preparation kits for inputs down to 50 pg
- MicroPlex Library Preparation kit: Low inputs of 50 pg in a simple 3-step workflow
- iDeal Library Preparation: Inputs above 5 ng, optimized with our iDeal ChIP-seq kit
The field of human disease diagnostics is also changing and growing at a rapid rate. Diagenode offers amplification and quantification methods for DNA targets of human infectious disease. We also provide guidance to diagnostics companies developing epigenetics-based diagnostics. Our products are designed to make diagnostic assays simpler, faster, and more convenient, with the highest levels of quality. Our kits are CE-marked and certified ISO 9001 and ISO 13485.