The latest tool for CRISPR gene editing is a new CRISPR-C2C2 (Cas13a) system which utilizes RNA-guided RNA-targeting for RNA knockdown and binding in cells. C2C2 (Cas13a) may be useful for isolating specific RNA sequences or even studying single RNA molecules with high specificity. Unlike editing DNA as with Cas9 which makes permanent genomic changes, targeting RNA with C2C2 allows temporarily altering the amount of protein potentially offering a better therapeutic approach in the future.
Use Diagenode's new C2C2 (Cas13a) polyclonal antibody to determine precision and success metrics in CRISPR experiments.
