UBA1 recombinant protein
UBA1A, UBE1, UBE1X, A1S9, A1S9T, AMCX1, SMAX2, A1ST, GXP1, CFAP124, POC20
UBA1 (UniProt/Swiss-Prot entry P22314) is catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It activates ubiquitin by adenylating the C-terminal glycine residue with ATP and subsequently linking the adenylated glycine to the side chain of a cysteine residue in E1 thereby forming a ubiquitin-E1 thioester. UBA1 is also required for DNA repair response to replication stress.
Purified using FPLC, >95% purity as determined by SDS-PAGE.
20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
Store at-80°C; guaranteed stable for 2 years from date of receipt when stored properly.
Precautions: This product is for research use only. Not for use in diagnostic or therapeutic procedures.