Diagenode

Recombinant human Tif1 alpha (Trim24)

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Catalog Number
Format
Price
C23010109
10 µg
$340.00

Full length recombinant human N-terminal Flag tagged TRIM24 (Tripartite Motif Containing 24) protein, produced in SF9 insect cells.

  • Product Description

    TRIM24 recombinant protein

    Other names

    TIF1A, TIF1, TF1A, HTIF1, RNF82, PTC6

    Target description

    TRIM24 (UniProt/Swiss-Prot entry O15164) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. It acts as a a transcriptional coactivator through it’s interaction with several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors, and coactivators thereby modulating the transcription of target genes. TRIM24 is thought to associate with chromatin. This association depends on histone H3 modifications with the highest affinity for histone H3 that is both unmodified at 'Lys-4' and acetylated at 'Lys-23'. Defects in TRIM24 cause thyroid papillary carcinoma.

    Concentration

    0.5µg/µl

    Specificity 

    Human

    Purity

    Purified using FPLC, >95% purity as determined by SDS-PAGE.

    Storage Buffer

    20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.

    Storage

    Store at-80°C; guaranteed stable for 2 years from date of receipt when stored properly.

    Precautions: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

  • Quality Control

    Figure 1.
    SDS page of the TRIM24 recombinant protein. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.

  • Documents
    TRIM24 recombinant protein DATASHEET
    Datasheet of TRIM24 recombinant protein
    Download
  • Publications

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