Diagenode

Recombinant human MBD4

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Catalog Number
Format
Price
C23010108
10 µg
$340.00

Active full length recombinant human N-terminal His tagged MBD4 (Methyl-CpG Binding Domain Protein 4) protein, produced in SF9 insect cells.

  • Product Description

    MBD4 recombinant protein

    Other names

    MED1

    Target description

    MBD4 (UniProt/Swiss-Prot entry O95243) belongs to the family of methyl CpG binding proteins that specifically bind to methylated CpG dinucleotides. MBD4 probably functions to mediate the biological consequences of CpG methylation. Further, MBD4 has thymine glycosylase activity and is involved in DNA mismatch repair. It is specific for G/T mismatches within methylated and unmethylated CpG sites Mutations of MBD4 are associated with tumors with primary microsatellite-instability, a type of genomic instability that is caused by a defective DNA mismatch repair.

    Concentration

    0.5µg/µl

    Specificity 

    Human

    Purity

    Purified using FPLC, >95% purity as determined by SDS-PAGE.

    Storage Buffer

    20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.

    Storage

    Store at-80°C; guaranteed stable for 2 years from date of receipt when stored properly.

    Precautions: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

     

  • Quality Control

    Figure 1.
    SDS page of the MBD4 recombinant protein. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.

  • Documents
    MBD4 recombinant protein DATASHEET
    Datasheet of MBD4 recombinant protein
    Download
  • Publications

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    Oct 3-Oct 8, 2016
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