Diagenode

Recombinant Histone H2A.X

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Catalog Number
Format
Price
C23010005
100 μg
$230.00

Full length recombinant histone H2A.X, produced in E. coli.

  • Protein description

    Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. The histone variant H2AX replaces conventional H2A in a subset of nucleosomes. H2AX plays a central role in DNA repair and chromosomal stability and is required for cell cycle progression arrest in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks.

  • Quality control

    Figure 1.
    SDS page of the Recombinant Histone H2A.X. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.

  • Documents
    C23010005 histone H2AX DATASHEET
    C23010005 histone H2AX tds
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  • Publications

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    Oct 3-Oct 8, 2016
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