Diagenode

Recombinant human Tif1 gamma (Trim33)

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Catalog Number
Format
Price
C23010110
10 µg
$350.00

Full length recombinant human N-terminal Flag tagged TRIM33 (Tripartite Motif Containing 33) protein, produced in SF9 insect cells.

  • Product Description

    TRIM33 recombinant protein

    Other names

    TIF1G, TIF1gamma, TF1G, RFG7, ECTO, PTC7

    Target description

    TRIM33 (UniProt/Swiss-Prot entry Q9UPN9) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. TRIM33 is an E3 ubiquitin-protein ligase, which promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. It may act as a transcriptional corepressor and inhibits the transcriptional response to the TGF-beta/BMP signaling cascade. However, molecules that interact with this protein have not yet been identified..TRIM33 also plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Defects in TRIM24 cause thyroid papillary carcinoma.

    Concentration

    0.5µg/µl

    Specificity 

    Human

    Purity

    Purified using FPLC, >95% purity as determined by SDS-PAGE.

    Storage Buffer

    20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.

    Storage

    Store at-80°C; guaranteed stable for 2 years from date of receipt when stored properly.

    Precautions: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

  • Quality Control

    Figure 1.
    SDS page of the TRIM33 recombinant protein. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.

  • Documents
    TRIM33 recombinant protein DATASHEET
    Datasheet of TRIM33 recombinant protein
    Download
  • Publications

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