TRIM24 recombinant protein
Other names
TIF1A, TIF1, TF1A, HTIF1, RNF82, PTC6
Target description
TRIM24 (UniProt/Swiss-Prot entry O15164) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. It acts as a a transcriptional coactivator through it’s interaction with several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors, and coactivators thereby modulating the transcription of target genes. TRIM24 is thought to associate with chromatin. This association depends on histone H3 modifications with the highest affinity for histone H3 that is both unmodified at 'Lys-4' and acetylated at 'Lys-23'. Defects in TRIM24 cause thyroid papillary carcinoma.
Concentration
0.5µg/µl
Specificity
Human
Purity
Purified using FPLC, >95% purity as determined by SDS-PAGE.
Storage Buffer
20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
Storage
Store at-80°C; guaranteed stable for 2 years from date of receipt when stored properly.
Precautions: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
