PRMT5 recombinant protein
SKB1, HRMT1L5, SKB1Hs, IBP72, JBP1
PRMT5 (UniProt/Swiss-Prot entry O14744) is an arginine methyltransferase that can both catalyze the monomethylation and symmetrical dimethylation of arginine residues with a preference for the formation of monomethylarginine, in a variety of proteins including SNRPD1, SNRPD3, SUPT5H, MBP, PIWIL1, PIWIL2, PIWIL4, HOXA9, SRGAP2 and histone H2A, H4 and H3. Histone H2A and H4 are methylated at R3 during germ cell development, whereas histone H3 is methylated at R8, probably leading to transcriptional repression.
Purified using FPLC, >95% purity as determined by SDS-PAGE.
20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
Store at-80°C; guaranteed stable for 2 years from date of receipt when stored properly.
Precautions: This product is for research use only. Not for use in diagnostic or therapeutic procedures.