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<h4>Other names</h4>
<p>AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RTS, RTT</p>
<h4>Target description</h4>
<p>MeCP2 (UniProt/Swiss-Prot entry P51608) is a chromosomal protein with abundant binding sites in the chromatin. It belongs to the family of methyl CpG binding proteins which also comprises MBD1, MBD2, MBD3 and MBD4. MeCP2 can bind specifically to methylated promoters, thereby repressing transcription. This transcriptional repression is mediated through interaction with histone deacetylase and the corepressor SIN3A. MeCP2 also is essential for development. Mutations in MeCP2 are the cause of several types of mental retardation including Rett syndrome, a progressive neurological disorder that causes mental retardation in females and mental retardation syndromic X-linked type 13, and may also be involved in Angelman syndrome and susceptibility to some types of autism.</p>
<h4>Concentration</h4>
<p>0.5µg/µl</p>
<h4>Specificity </h4>
<p>Human</p>
<h4>Purity</h4>
<p>Purified using FPLC, >95% purity as determined by SDS-PAGE.</p>
<h4>Storage Buffer</h4>
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<p><small><strong>Figure 1.</strong><br />MeCP2 activity assay. A 70 bp methylated DNA (50 ng) was incubated with increasing amounts of MeCP2 (lane 2 - 4) at room temperature for 30 min and immediately analyzed on a native polyacrylamide gel. A negative control (no addition of MeCP2) is shown in lane 1.</small></p>
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<h4>Other names</h4>
<p>TIF1A, TIF1, TF1A, HTIF1, RNF82, PTC6</p>
<h4>Target description</h4>
<p>TRIM24 (UniProt/Swiss-Prot entry O15164) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. It acts as a a transcriptional coactivator through it’s interaction with several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors, and coactivators thereby modulating the transcription of target genes. TRIM24 is thought to associate with chromatin. This association depends on histone H3 modifications with the highest affinity for histone H3 that is both unmodified at 'Lys-4' and acetylated at 'Lys-23'. Defects in TRIM24 cause thyroid papillary carcinoma.</p>
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<p><small><strong>Figure 1.</strong><br />SDS page of the TRIM24 recombinant protein. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</small></p>
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<p>HP1 beta (UniProt/Swiss-Prot entry P83916) is a component of heterochromatin. It recognizes and binds to histone H3 tails methylated at 'Lys-9', leading to epigenetic repression of transcription. HP1b does not associate with chromosomes during mitosis. It may also interact with lamin B receptor (LBR), thereby contributing to the association of the heterochromatin with the inner nuclear membrane.</p>
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<p>0.5µg/µl</p>
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<p><small><strong>Figure 1.</strong><br />SDS page of the HP1ß recombinant protein. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</small></p>
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<h2>Optimize your experiments thanks to our <br /><span class="red">new recombinant proteins</span>!</h2>
<h5>These new <strong>pure</strong> and <strong>full length</strong> recombinant proteins are ideal standards. Use them for Western Blot or ELISA control experiments, generating antibodies and studying structural biology.</h5>',
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<h6 style="height:60px">Recombinant human Hp1 beta (CBX1)</h6>
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<p><small><strong>Figure 1.</strong><br />SDS page of the HP1ß recombinant protein. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</small></p>
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<h2>Optimize your experiments thanks to our <br /><span class="red">new recombinant proteins</span>!</h2>
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<p>MeCP2 (UniProt/Swiss-Prot entry P51608) is a chromosomal protein with abundant binding sites in the chromatin. It belongs to the family of methyl CpG binding proteins which also comprises MBD1, MBD2, MBD3 and MBD4. MeCP2 can bind specifically to methylated promoters, thereby repressing transcription. This transcriptional repression is mediated through interaction with histone deacetylase and the corepressor SIN3A. MeCP2 also is essential for development. Mutations in MeCP2 are the cause of several types of mental retardation including Rett syndrome, a progressive neurological disorder that causes mental retardation in females and mental retardation syndromic X-linked type 13, and may also be involved in Angelman syndrome and susceptibility to some types of autism.</p>
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<p><small><strong>Figure 1.</strong><br />SDS page of the HP1ß recombinant protein. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</small></p>
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<h2>Optimize your experiments thanks to our <br /><span class="red">new recombinant proteins</span>!</h2>
<h5>These new <strong>pure</strong> and <strong>full length</strong> recombinant proteins are ideal standards. Use them for Western Blot or ELISA control experiments, generating antibodies and studying structural biology.</h5>',
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'url' => 'files/products/reagents/C23010106-mecp2-recombinant-protein.pdf',
'slug' => 'C23010106-mecp2-recombinant-protein',
'meta_keywords' => '',
'meta_description' => '',
'modified' => '2015-11-04 16:25:22',
'created' => '2015-11-04 16:25:22',
'ProductsDocument' => array(
'id' => '1266',
'product_id' => '2725',
'document_id' => '847'
)
)include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118
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