HP1g recombinant protein
CBX3, HECH, HP1 gamma
HP1 gamma (UniProt/Swiss-Prot entry Q13185) is a component of heterochromatin. It recognizes and binds to histone H3 tails methylated at 'Lys-9', leading to epigenetic repression of transcription. HP1g may also interact with lamin B receptor (LBR), thereby contributing to the association of the heterochromatin with the inner nuclear membrane. HP1g is recruited to sites of ultraviolet-induced DNA damage and double-strand breaks and may be associated with microtubules and mitotic poles during mitosis.
Purified using FPLC, >98% purity as determined by SDS-PAGE.
20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
Store at-80°C; guaranteed stable for 2 years from date of receipt when stored properly.
Precautions: This product is for research use only. Not for use in diagnostic or therapeutic procedures.