Recombinant Histone H3.3 K27M

Catalog Number
50 µg

Full length recombinant histone H3.3 in which Lys27 was mutated to Met; produced in E. coli.

  • Protein description

    Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. The histone variant H3.3 replaces conventional H3.1 in a wide range of nucleosomes in active genes. H3.3 constitutes the predominant form of histone H3 in non-dividing cells. The K27M mutation was identified in several human pediatric glioblastoma tumors.

  • Quality control

    Figure 1.
    SDS page of the Recombinant Histone H3.3 K27M. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.

    Figure 2.
    ESi-TOF analysis of Recombinant Histone H3.3 K27M

  •  Documents
    C23010009 histone H3.3 K27M DATASHEET
    C23010009 histone-H.3 K27M tds
  •  Publications

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