- Genome-wide screening for DNA methylation - Library preparation of bisulfite-converted DNA from whole genomes
- Compatible with ChIP-Bis-Seq - Combines ChIP and DNA methylation profiles in one assay
- Complete kit – Bisulfite conversion reagents and library preparation reagents
Figure 1: ChIP-Bis-sequencing results obtained with the Diagenode’s Premium WGBS Kit
A. Chromatin immunoprecipitation against the H3K27me3 mark was performed using the Diagenode’s iDeal ChIP-seq Kit for Histones on a Gm12878 human cell line. The library was then prepared using the MicroPlex Library Preparation Kit and sequenced. The peaks represent the distribution of the reads. B. The ChIP’d DNA was then further processed with the Premium WGBS Kit and sequenced. The distribution of the reads is shown in black. The methylated CpGs are shown in red and the unmethylated CpGs in blue. Each peak represents the DNA methylation percentage at one CpG.