Human Native Nucleosome

Catalog Number
20 µg

Human native nucleosomes purified from HeLa cells, digested with micrococcal nuclease.

  • Protein description

    The nucleosome is the smallest part of the chromosome. It consists of two core histones of each class H2A, H2B, H3 and H4 which assemble and are wrapped around 146 base pairs of DNA. Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They pack the DNA into tight masses of chromatin. Histones are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes.



  • Quality control

    Figure 1.
    Agarose gel analysis of the human native nucleosome. The position of the mono and di-nucleosomes is indicated on the right; the marker (in bp) is shown on the left.

    Figure 2.
    SDS-PAGE gel analysis of the human native nucleosome. The position of the four core histones is indicated on the right; the marker (in kDa) is shown on the left.

  •  Documents
    C01030102 human native nucleosome DATASHEET
    C01030102 human native nucleosome tds
  •  Publications

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