ChIP-qPCR
Chromatin Immunoprecipitation (ChIP) coupled with quantitative PCR can be used to investigate protein-DNA interaction at known genomic binding sites. if sites are not known, qPCR primers can also be designed against potential regulatory region... Read more
Diagenode strongly recommends using this: HighCell# ChIP kit protein A x16 (Diagenode Cat# C01010060). Click here to copy to clipboard.
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RNA-binding protein HuR enhances mineralocorticoid signaling in renal KC3AC1 cells under hypotonicity Lema I. et al. Mineralocorticoid receptor (MR) mediates the sodium-retaining action of aldosterone in the distal nephron. Herein, we decipher mechanisms by which hypotonicity increases MR expression in renal principal cells. We identify HuR (human antigen R), an mRNA-stabilizing protein, as an important posttranscriptional re...
Stem cell-like transcriptional reprogramming mediates metastatic Mateo F. et al. Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown. Here, complementary studies in human tumors, cancer models and cell lines ...
Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells Le Billan F. et al. Aldosterone exerts its effects mainly by activating the mineralocorticoid receptor (MR), a transcription factor that regulates gene expression through complex and dynamic interactions with coregulators and transcriptional machinery, leading to fine-tuned control of vectorial ionic transport in the distal nephron. To...
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