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Unravel the hidden mysteries of histones, nucleosomes and chromatin with our new epigenetic tools!


Diagenode now offers a broad range of tools to study nucleosomes and histones, the structural and functional units of chromatin. We provide solutions for any architectural level of regulation with the best quality recombinant human histones, native or recombinant nucleosomes or chromatin assembly kit.

These new tools are the easiest, quickest and most effective way to study in vitro histone post-translational modifications, nucleosome variants, nucleosome distribution and general chromatin structure. In addition, they allow you to perform enzyme activity assays or drug screening.

Recombinant human histones

  • Excellent ultra-pure human recombinant histone produced in E. coli
  • Suitable for in vitro chromatin assembly
  • Ideal substrate for analysis of histone post-translational modifications including acetylation, methylation, ubiquitination, sumoylation and phosphorylation
  • Optimal for inhibitor and drug screening

SDS-PAGE gel of recombinant Histone H2A (Lane 2). Lane 1, protein molecular weight marker.



Native or recombinant nucleosomes

  • Excellent ultra-pure recombinant nucleosome assembled in vitro or native nucleosome purified from Hela cell nuclei
  • Save time and effort by providing pre-assembled nucleosomes
  • Suitable for in vitro chromatin assembly
  • Ideal substrate to study structural changes induced by the histones variants and histones mutations
  • Optimal for enzymatic methyltransferase assay and small molecule inhibitor screening

SDS-PAGE gel of human native nucleosomes.



Chromatin Assembly Kit

The Chromatin Assembly Kit enables a method to mimic the nucleosome environment and closely model the chromatin architecture.

  • Complete kit including nucleosomes
  • Quick assembly in less than 6 hours
  • Optimal for downstream applications such in vitro ChIP, histone modification or enzymatic screening

Events

  • DNA methylation workshop: Become an expert at RRBS
    Diagenode
    Oct 1-Oct 31, 2021
  • Dutch Chromatin Meeting
    Radboud UMC, Geert Grooteplein 15, 6525 EZ Nijmegen, The Netherlands, Experience center, route 292 to 307
    Nov 12, 2021
 See all events

News

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The European Regional Development Fund and Wallonia are investing in your future.

Extension of industrial buildings and new laboratories.



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