Diagenode provides the new True MicroChIP kit with optimized reagents and protocol to enable successful ChIP on as few as 10 000 cells. Moreover, the True MicroChIP kit protocol has been thoroughly optimised by Diagenode for ChIP followed by high-throughput sequencing on Illumina® Next-Gen sequencers. To allow the generation of consistant results in ChIP-seq on 10 000 cells, Diagenode has also optimised a library preparation protocol on limited amount of immunoprecipitated DNA. The new MicroPLEX library preparation kit allows the preparation of libraries for sequencing on picogram amount of immunoprecipitated DNA. Thus, association of the True MicroChIP kit with the MicroPLEX library preparation kit provides optimised solutions to perform ChIP-sequencing on limited amount of cells.