This MethylCap kit includes the methylCap protein (Cat. No. mbd-001-100) which has been extensively validated. It consists of the methyl binding domain (MBD) of human MeCP2, as a C-terminal fusion with Glutathione-S-transferase (GST) containing an N-terminal His6-tag. The MethylCap protein can be used to specifically isolate DNA containing methylated CpGs.