Diagenode provides a full solution for your every epigenetics research need

ChIP-seq results on PGM™

Validation of iDeal ChIP-Seq kit with Ion Torrent™ PGM™ Sequencer

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Poster

See ChIP data from less than 200 cells

Bioruptor® NGS

Unbiased DNA shearing for genomic library sequencing

Diagenode provides a solution for your every epigenetics research need in stem cell research

In recent years, studies suggest that the mammalian genome undergoes various epigenetic modifications during development and embryonic stem cell (ESC) differentiation. Understanding the mechanisms that control these epigenetic signals is essential in deciphering stem cell biology and the patterns of gene expression during cellular differentiation. ESC gene expression relies heavily on transcriptional factor networks and epigenetic signals that give stem cells their ability to differentiate into different cell types -- histone modification, histone variants, DNA methylation, and non-protein-coding RNAs.

Accelerate your stem cell studies with flexible tools for epigenetics analysis methods including Next Generation Sequencing

Sonication systems for optimal NGS library preparation, chromatin & DNA shearing, and more! Learn why we beat other competing systems like Covaris.
DNA methylation kits
Sensitive, fast, and NGS-compatible.
ChIP kits for industry-leading specificity and sensitivity.
Don't just take our word for it. See our poster.
High class and validated antibodies with Chip-Seq grade antibodies, hMc antibodies, and more.

Publications Referencing Diagenode Products

Using the Diagenode LowCell ChIP kit

Moreno-Manzano V, Rodríguez-Jiménez FJ, Aceña-Bonilla JL, Fustero-Lardíes S, Erceg S, Dopazo J, Montaner D, Stojkovic M, Sánchez-Puelles JM, FM19G11, A new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status., J Biol Chem, 2010-01-08, 285, 1333-42, http://www.pubmed.org/19897487/

Using the Diagenode Bioruptor
for chromatin shearing, Shearing Buffer, OneDay ChIP kit and rabbit IgG

Tamm C, Böwer N, Annerén C, Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF, J Cell Sci, 2011-04-01, 124, 1136-44, http://www.pubmed.org/21385842

Using the Diagenode MeDIP kit

Santourlidis S, Wernet P, Ghanjati F, Graffmann N, Springer J, Kriegs C, Zhao X, Brands J, Araúzo-Bravo MJ, Neves R, Koegler G, Uhrberg M, Unrestricted somatic stem cells (USSC) from human umbilical cord blood display uncommitted epigenetic signatures of the major stem cell pluripotency genes., Stem Cell Res, 2011-01-01, 6, 60-9, http://www.pubmed.org/20933485

Check out the most validated antibodies on the market for Epigenetics