Expertise | Sonication

Most cited ultrasonicator

Parallel-processing Ultrasonicators with Adaptive Cavitation Technology

Diagenode's Bioruptor® ultrasonicator devices are engineered to deliver highly-controlled ultrasonic energy to biological or chemical samples using ACT (Adaptive Cavitation Technology). ACT is a non-contact, parallel-processing and isothermal technology.

Bioruptor® is the most popular brand in the Epigenetic and Next-Generation Sequencing communities with several hundred citations in peer-reviewed journals. Our instruments provide processing performance and recovery unmatched by any other sample preparation methodology. ACT allows to standardize sample prep for a range of applications including: DNA shearing for Next-Generation Sequencing, chromatin shearing, nucleic acids or protein extraction, cell lysis, nanotubes generation, and more.

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"Because of its easy usage and robust technology, I use the Bioruptor for all sonication applications, e. g. cell disruption, DNA shearing and Chromatin immunoprecipitation. I like that I can process several samples at once without overheating due to the thermo-cooling system, thus increasing reproducibility and speeding up my experiments."

Dr. Holger Bierhoff, Molecular Biology of the Cell II (A030), Prof. Dr. Ingrid Grummt's lab,
German Cancer Research Center, Heidelberg, Germany

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"The Bioruptor®* NGS is a robust user-friendly sonication system that is key for both reproducible chromatin shearing and DNA shearing. The Bioruptor® NGS consistently delivered optimal DNA shearing that was critical in generating homogeneous sequencing libraries for our experiments. We also observed excellent chromatin shearing results that were crucial for our epigenetic mapping projects."

Dr. Sascha Tierling, Departement of Genetics and Epigenetics, Prof. Dr. Jörn Walter's lab,
Universität des Saarlandes, Germany

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The table below will help you to choose the best Bioruptor® for your applications.

Product Specifications Applications & Performance Features
Bioruptor® Pico
Advanced shearing device
All-in-one solution with advanced timing control & regulated cooling.
Sample size : 5 µl – 2 ml
  • Next-Gen Seq
    (5 – 100 µl)
  • Chromatin shearing
    (10 µl – 2 ml)
  • RNA shearing
  • Cell & Tissue disruption
Chromatin shearing
DNA & RNA shearing
Throughput
Consistency
Thermo-control
Processing time
Programming
  • All in one solution
  • Simultaneous sonication of
    6 – 12 samples
  • Small & light
  • Easy-to-use & install
  • Temperature-controlled
  • No soundproof box
Bioruptor® Plus
Advanced shearing device
Advanced timing control & regulated cooling (optional for EU).
Sample size: 100 µl – 20 ml
  • Chromatin shearing
  • DNA shearing
  • Cell & Tissue disruption
  • Others
Chromatin shearing
DNA shearing
Cell & Tissue disruption
Throughput
Consistency
Thermo-control
Processing time
Programming
  • All in one solution (US, optional for EU)
  • Simultaneous sonication of
    3 – 12 samples
  • Easy-to-use & install
  • Temperature-controlled (US, optional for EU)
Bioruptor® Standard
Only available in the US
Basic shearing device
Manual timing control & cooling (continuous valve or crushed ice).
Sample size: 100 µl – 20 ml
  • Chromatin shearing
  • DNA shearing
  • Cell & Tissue disruption
  • Others
Chromatin shearing
DNA shearing
Cell & Tissue disruption
Throughput
Consistency
Thermo-control
Processing time
Programming
  • Simultaneous sonication of
    3 – 12 samples
  • Easy-to-use & install
  • Temperature-controlled (optional)

New! Thermo-Control Device

  • Smaller device
  • Lighter
  • Water drain
  • Easy control of water level
  • More fancy features

New! Single Cycle Valve

  • Easy set-up
  • Compact design

 

Compatible with Bioruptor® : Plus (B01020001) or Pico (B01060001)

 

>> More info about Diagenode's Ultrasonicators